Last edited by Dokinos
Wednesday, August 12, 2020 | History

10 edition of Therapeutic Proteins found in the catalog.

Therapeutic Proteins

Methods and Protocols (Methods in Molecular Biology)

  • 143 Want to read
  • 33 Currently reading

Published by Humana Press .
Written in English

    Subjects:
  • Medical,
  • Medical / Nursing,
  • Biochemistry,
  • Life Sciences - Biochemistry,
  • Pharmacology,
  • Science / Biochemistry,
  • Nursing - Pharmacology,
  • Laboratory manuals,
  • Protein drugs,
  • Proteins,
  • chemical synthesis,
  • therapeutic use

  • Edition Notes

    ContributionsC. Mark Smales (Editor), David C. James (Editor)
    The Physical Object
    FormatHardcover
    Number of Pages496
    ID Numbers
    Open LibraryOL12325610M
    ISBN 101588293904
    ISBN 109781588293909

    Aggregation of Therapeutic Proteins provides an up-to-date resource on protein aggregation and its consequences, and available methods to control or slow down the aggregation process. This book also covers an overview on the causes, consequences, characterization, and control of the aggregation of therapeutic proteins. At the outset, one is impressed with the scope of the book; it provides an outline of very diverse topics, starting with the basics of protein engineering and how these are used to design and manipulate the ADME properties of recombinant and synthetic proteins (Chapters 2 and 3).Cited by: 1.

      This arrangement creates a more logical flow than the book's first edition. A few shortcomings detract from the text. One flaw is that important content is excluded. For example, a mention of the pharmacokinetics of therapeutic peptides and proteins would have been useful to metabolism and pharmacokinetics scientists. Title:Therapeutic Proteins: A to Z VOLUME: 20 ISSUE: 12 Author(s):Aykut Ozgur and Yusuf Tutar Affiliation:Department of Biochemistry, Faculty of Pharmacy, Cumhuriyet University, Sivas, Turkey. Keywords:Therapeutic proteins, recombinant DNA technologies, monoclonal antibodies, interferons, insulin and erythropoietin. Abstract:In recent years, therapeutic proteins have become an important.

    This procedure has proven to be successful and promises to provide a method for producing valuable therapeutic proteins at much lower cost. 1 R.M. Akers, et al., in Recombinant DNA Technology, vol. 2: Special Issue of Annals of the New York Academy of Science, vol. , pp. , May 2, Book reVIew This new, comprehensive text published by Wiley Blackwell provides a much needed re-write on the earlier publication of 15 y ago,1 published just after the approval of the first Fc-fusion protein, etanercept (Enbrel®). The field of therapeutic proteins, dominated by .


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Therapeutic Proteins Download PDF EPUB FB2

It is a valuable book for those readers working in the development of biologics but also for the general readers interested in how the most advanced and sophisticated drugs are developed.” (ChemMedChem, 1 February ) "I found Therapeutic Fc-Fusion Proteins to be thorough, timely and well written This book would be of interest to a.

The knowledge in this book can greatly help pharmaceutical scientists in the development of therapeutic proteins, and also instigate further scientific investigations in this area. This book fills such a need by providing an overview on the causes, consequences, characterization, and control of Therapeutic Proteins book aggregation of therapeutic proteins.

Building on the valuable first edition, Therapeutic Proteins: Methods and Protocols, Second Edition aims to cover each of these key aspects of protein drug production through the contributions of authors from highly esteemed industrial and academic institutions around the world.

Emphasizing the newest developments in the field, this second. The knowledge in this book can greatly help pharmaceutical scientists in the development of therapeutic proteins, and also instigate further scientific investigations in this area.

This book fills such a need by providing an overview on the causes, consequences, characterization, and control of the aggregation of therapeutic proteins.5/5(2).

Fully updated and practical, Therapeutic Proteins: Methods and Protocols, Second Edition provides an essential resource to all scientists working in the field of therapeutic proteins. Product details Series: Methods in Molecular Biology (Book )5/5(1).

Authoritative and highly practical, Therapeutic Proteins: Methods and Protocols offers both novice and experienced researchers the latest innovative, readily reproducible techniques, as well as helpful commentaries on the development and production of therapeutic proteins, Therapeutic Proteins book from their expression to actual formulation.

Abstract. Therapeutic proteins require specific, stable formulations to permit their efficient use. Given the stringent timeline for most product development, many formulation scientists must rely on forced degradation studies using a limited number of techniques to analyze potential degradation events and underlying mechanisms.

therapeutic proteins, the b ioavailability of these therapeutic proteins follo wing the SC and/or IM route is known to face a large variety of di erences in terms o f lymph and blood.

This therapeutic approach in treating diseases using proteins and peptides is termed protein therapeutics. Protein therapy is similar to gene therapy, but unlike gene therapy, protein therapy delivers protein to the body in specific amounts (as would be ordinarily present), to help repair illness, treat pain or remake structures.

Introduced in. Therapeutic Protein. Therapeutic proteins are quite diverse in the application treatments, such as human insulin for diabetes, erythropoietin for anemia and chronic renal failure, interferon-beta and gamma for cancer, DNase for pulmonary treatment, vaccines for Hepatitis B, Interleukin-2 for AIDS, Prourokinase for heart attacks, tissue plasminogen activator (enzyme) for strokes, and in many.

Engineering of Therapeutic Proteins post-translational modification, protein fusions, and genetic engineering, as illus-trated in Figure strategies for improving Pharmacokinetics The efficacy of a therapeutic protein in the human body can be improved by a number of strategies, including fusions, glycosylation, and chemical Size: 1MB.

Therapeutic Proteins and Peptides, Volume in an ongoing series promotes further research in the discovery of new therapeutic targets that can be affected by therapeutic proteins and peptides to cure or manage symptoms of human diseases, with this release focusing on the Rational Design of Stable Liquid Formulations of Biopharmaceuticals, Formulation strategies for peptides, proteins and.

Therapeutic benefits of altering proteins with PEG include an improvement in half-life due to reduced renal and cellular clearance, enhanced protection from proteolysis and a reduction in toxicity Author: Karen Nagel.

The knowledge in this book can greatly help pharmaceutical scientists in the development of therapeutic proteins, and also instigate further scientific investigations in this area. This book fills such a need by providing an overview on the causes, consequences, characterization, and control of the aggregation of therapeutic proteins.

of therapeutic proteins, and also instigate further scientific investigations in this area. This book fills such a need by providing an overview on the causes, consequences, characterization, and control of the aggregation of therapeutic proteins.

Book Annex Membership Educators Gift Cards Stores & Events Help. Auto Suggestions are available once you type at least 3 letters. Use up arrow (for mozilla firefox browser alt+up arrow) and down arrow (for mozilla firefox browser alt+down arrow) to review and enter to : $ Read "Therapeutic Proteins Strategies to Modulate Their Plasma Half-lives" by available from Rakuten Kobo.

For this ready reference, the internationally renowned authority in the field, Roland Kontermann, has assembled a team o Brand: Wiley. Bibliography Includes bibliographical references and index. Contents. Biopharmaceutical Proteins: Opportunities and Challenges John R. Birch and Yemi Onakunle Expression of Antibody Fragments by Periplasmic Secretion in Escherichia coli Andrew G.

Popplewell, Mukesh Sehdev, Mariangela Spitali, and A. Neil C. Weir Secretory Production of Therapeutic Proteins in Escherichia coli Sang Yup Lee. A biopharmaceutical, also known as a biologic(al) medical product, or biologic, is any pharmaceutical drug product manufactured in, extracted from, or semisynthesized from biological sources.

Different from totally synthesized pharmaceuticals, they include vaccines, blood, blood components, allergenics, somatic cells, gene therapies, tissues, recombinant therapeutic protein, and living. Therapeutic proteins are the engineered proteins in the laboratory intended for pharmaceutical use.

The first therapeutic protein was Insulin, used for treating Diabetes in the ’s. Under definite conditions, recombinant DNA technology makes it easy to produce proteins in particular host cells such as bacteria, yeast, or mammalian cells/5(35).

World-class researchers share their innovative and proven techniques for the production of therapeutic proteins downstream of the discovery stage. The methods use a variety of sources for producing therapeutic proteins, including bacterial and yeast expression systems, and insect and mammalian Price: $Therapeutic Proteins: Methods and Protocols covers all aspects of protein drug production downstream of the discovery stage.

This volume contains contributions from leaders in the field of therapeutic protein expression, purification, characterization, f- mulation, and viral inactivation.". Figure 1. Complexity of therapeutic protein drugs.

(a) Graphical representation of the complexity of the manufacture of a therapeutic protein drug compared with a small-molecule number of batch records, product quality tests, critical process steps, and process data entries associated with small-molecule drugs (black) and therapeutic protein drugs (grey) as bars by: